Coletix®

From the constant research of the Yamamoto® Research R&D team comes Coletix, a food supplement based on Olecol® certified olive extract, fermented red rice (Monascus purpureus), gamma oryzanol and completed with coenzyme Q10, which thanks to the synergy of the active ingredients contained supports good blood circulation and regular blood pressure. Coletix provides 58 mg/daily dose of fermented red rice titrated at 2.76% in total monacolins (2.76 mg per daily dose, in compliance with the new European regulations on the use of Monacolin K).

Cardiovascular diseases are now among the main causes of disability and mortality in Western and developing countries, and are favored by unhealthy lifestyles, unbalanced diet, excess “junk food”, little or no physical activity, and smoking. The main factors that influence the propensity to cardiovascular diseases and disorders are cholesterol imbalance (hypercholesterolemia), hypertriglyceridemia, hypertension, diabetes and insulin resistance, in addition to obesity. Specifically, it is good to keep the entire lipid balance under control in order to protect yourself from the formation of atherosclerotic plaques along the walls of blood vessels, favored by inflammation and hypertension, which will potentially risk obstructing the vessels and causing very serious consequences on the cardiovascular system.

Coletix is the product that Yamamoto® Research has developed to promote and support good blood circulation, heart health and maintain normal levels of triglycerides in the blood. A titrated and standardized plant extract was chosen for the formulation, which allows the natural active ingredients to be kept qualitatively and quantitatively constant, ensuring the product stability, bioavailability and efficacy. The product has the following synergies:

• Olecol® olive extract;
• Red fermented rice;
• Gamma oryzanol;
• Coenzyme Q10.

In detail, Monacolin K from red fermented rice is a molecule belonging to the Monacolin group, which originates from the fermentation of the common red cooking rice Oryza sativa thanks to the action of the yeast Monascus purpureus, also called “red yeast“, which gives it its characteristic color. Always used in oriental cuisine as a substitute for vinegar and as a health agent, the fermentation of this rice allows to obtain numerous substances, the monacolins, which perform a cholesterol-lowering action. Traditional Chinese Medicine suggests the consumption of fermented red rice to treat circulatory disorders and also in cases of gastrointestinal problems, but the discovery of the molecule to which many of the beneficial characteristics are attributed dates back to 1979. In that year, Professor Aika Endo, studying the fermentation of “red yeast”, discovered that a metabolite produced in the fermentation process could inhibit the enzyme HMG-CoA-reductase, one of the main enzymes involved in the synthesis of cholesterol (which occurs at the liver level): this metabolite was precisely Monacolin K.

Plant-based statins, such as Monacolin K, have been shown to possess anti-cholesterolemic properties. However, consumption must adhere to the recommended doses in compliance with current regulations, to avoid side effects such as weakness, muscle pain, gastrointestinal or liver problems.

Olive extract promotes normal blood circulation and regular blood pressure. The Oleuropein contained in Coletix is ​​represented by Olecol®, a patented Bioactor product, highly water-soluble, standardized, extracted from the Olive leaf, with a very high concentration of bioavailable Oleuropin, which has been shown to promote normal blood circulation and regular blood pressure thanks to a dual mechanism of action. It is a natural ingredient that offers a safe approach to the management of lipid levels in the blood, capable of fighting lipid oxidation and whose validity has also been demonstrated by multiple randomized and placebo-controlled studies.

Gamma oryzanol is a substance that is extracted from rice bran oil; it is also present in wheat bran, some fruits and some vegetables.

Coenzyme Q10, also known as ubiquinone due to its ubiquitous role in the body, is a very important molecule for our body. It is mainly present in the mitochondria, the energy centers of cells and also in the heart muscle, although it is present in many human tissues. It is involved in the electron transfer processes of the cell, and is a powerful antioxidant that protects membranes from oxidative damage. Since statins that lower cholesterol also reduce the production of Coenzyme Q10, it is very useful to replenish the levels of this substance when taking active ingredients, even natural ones, that could lower its physiological levels.

Scientific references

Özcan, M.M., Matthäus, B. A review: benefit and bioactive properties of olive (Olea europaea L.) leaves. Eur Food Res Technol 243, 89–99 (2017).https://doi.org/10.1007/s00217-016-2726-9

Lockyer S, Rowland I, Spencer JPE, Yaqoob P, Stonehouse W. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. Eur J Nutr. 2017 Jun;56(4):1421-1432. doi: 10.1007/s00394-016-1188-y. Epub 2016 Mar 7. PMID: 26951205; PMCID: PMC5486627.

Stevens Y, Winkens B, Jonkers D, Masclee A. The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial. Eur J Nutr. 2021 Jun;60(4):2111-2120. doi: 10.1007/s00394-020-02397-9. Epub 2020 Oct 9. PMID: 33034707; PMCID: PMC8137474.

Lockyer S, Rowland I, Spencer JPE, Yaqoob P, Stonehouse W. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. Eur J Nutr. 2017 Jun;56(4):1421-1432. doi: 10.1007/s00394-016-1188-y. Epub 2016 Mar 7. PMID: 26951205; PMCID: PMC5486627.

Mehmood A, Usman M, Patil P, Zhao L, Wang C. A review on management of cardiovascular diseases by olive polyphenols. Food Sci Nutr. 2020 Aug 13;8(9):4639-4655. doi: 10.1002/fsn3.1668. PMID: 32994927; PMCID: PMC7500788.

Cicero AFG, Fogacci F, Banach M. Red Yeast Rice for Hypercholesterolemia. Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):192-199. doi: 10.14797/mdcj-15-3-192. PMID: 31687098; PMCID: PMC6822657.

Goufo P, Trindade H. Rice antioxidants: phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. Food Sci Nutr. 2014 Mar;2(2):75-104. doi: 10.1002/fsn3.86. Epub 2014 Jan 21. PMID: 24804068; PMCID: PMC3959956.