Citrulline MALATE

Yamamoto® Nutrition’s Citrulline MALATE is a dietary supplement containing citrulline malate, a form of citrulline that binds to malic acid to create a compound that is easily absorbed by the body and suitable for athletes seeking superior performance. Taking Citrulline MALATE before exercise can improve the blood and oxygen supply to the muscles, by stimulating Nitric Oxide production, which increases resistance and improves performance during physical activities. Citrulline is a non-essential amino acid that plays various roles in the human body and, when taken in the form of dietary supplements, can offer several health benefits, particularly its effect on the cardiovascular system.

After intake, Citrulline is converted to L-arginine, which produces Nitric Oxide (NO), a potent molecule that dilates the blood vessels to allow working muscles to receive more oxygen and nutrients and at the same time rapidly remove metabolic waste. This effect on the blood flow results in improved performance and recovery in several respects, also involving the overall health of the cardiovascular system. In actual fact, Citrulline helps to reduce blood pressure and improve arterial health, can increase energy production and blood and oxygen flow to muscle tissue, consequently increasing stamina and reducing muscle fatigue. It is a molecule that acts as a key intermediate in the urea cycle, a metabolic step that serves to eliminate superfluous amine groups. This series of biochemical reactions allows the body to produce urea from ammonia, which is toxic for the body. When this molecule accumulates, it hampers the formation of muscle glycogen and promotes the onset of fatigue. Producing sufficient urea is therefore essential for eliminating the toxic substances that result in massive ammonia production, and citrulline supplementation enhances this activity. Citrulline can also help reduce muscle pain and fatigue after physical activity, by reducing lactic acid build-up in the muscles.

Another important effect of citrulline is its ability to support the production of arginine as a nitric oxide precursor. Nitric oxide-induced vasodilation is also used in the medical field to treat mild erectile dysfunction, as well as being exploited by athletes to enhance performance through an increased supply of blood, and therefore oxygen and nutrients, to the tissues involved in exertion.

Yamamoto® Nutrition Citrulline Malate is easy to take and incorporate into your daily routine. This supplement is manufactured in a GMP (Good Manufacturing Practice) certified plant, which ensures the highest quality and safety. The product has been laboratory-tested to ensure its purity and effectiveness.

Why is Citrulline Malate superior to simple Citrulline?

Citrulline Malate combines the amino acid Citrulline with Malate, an organic salt that plays an important role in various biochemical reactions, particularly in muscle tissue. Malic acid is one of the main components in the tricarboxylic acid cycle (TCA), a process by which the body produces energy. Combining Citrulline with Malate results in greater effectiveness in terms of vasodilation, performance and recovery from DOMS.

Scientific references

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Khalaf D, Krüger M, Wehland M, Infanger M, Grimm D. The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure. Nutrients. 2019 Jul 22;11(7):1679. doi: 10.3390/nu11071679. PMID: 31336573; PMCID: PMC6683098.

Farney TM, Bliss MV, Hearon CM, Salazar DA. The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants. J Strength Cond Res. 2019 Sep;33(9):2464-2470. doi: 10.1519/JSC.0000000000002356. PMID: 29176388.

Allerton TD, Proctor DN, Stephens JM, Dugas TR, Spielmann G, Irving BA. l-Citrulline Supplementation: Impact on Cardiometabolic Health. Nutrients. 2018 Jul 19;10(7):921. doi: 10.3390/nu10070921. PMID: 30029482; PMCID: PMC6073798.

Shiota A, Hotta Y, Kataoka T, Morita M, Maeda Y, Kimura K. Oral L-citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction. J Sex Med. 2013 Oct;10(10):2423-9. doi: 10.1111/jsm.12260. Epub 2013 Jul 11. PMID: 23844604.

Kiani AK, Bonetti G, Medori MC, Caruso P, Manganotti P, Fioretti F, Nodari S, Connelly ST, Bertelli M. Dietary supplements for improving nitric-oxide synthesis. J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E239-E245. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2766. PMID: 36479475; PMCID: PMC9710401.

Barassi A, Corsi Romanelli MM, Pezzilli R, Damele CA, Vaccalluzzo L, Goi G, Papini N, Colpi GM, Massaccesi L, Melzi d’Eril GV. Levels of l-arginine and l-citrulline in patients with erectile dysfunction of different etiology. Andrology. 2017 Mar;5(2):256-261. doi: 10.1111/andr.12293. Epub 2017 Feb 8. PMID: 28178400.