GLR® Setria®

Yamamoto® Research GLR® Setria® Sublingual is a food supplement in rapidly dissolving sublingual tablets that provides 250 mg per daily dose of L- Glutathione Reduced (Setria®) together with Vitamin C and Selenium. Glutathione is a powerful molecule with antioxidant action that plays a leading role in the body’s defense against oxidative stress and the action of free radicals and is able to protect hepatocytes from toxic molecules that could cause liver damage. The formulation in rapidly dissolving sublingual tablets allows the body to rapidly and optimally absorb Glutathione from the sublingual venous circulation tributary of the superior vena cava, bypassing the intestinal activity of gamma-glutamyltransferases and avoiding enterocyte metabolic avidity. In this way, the “liver filter” is skipped and the first-pass metabolism that usually occurs in the liver is avoided, which deactivates a large part of the Glutathione molecule, making it less functional and effective.

Glutathione is one of our first lines of defense, a ubiquitous molecule, that is, present throughout our organism, but it is particularly concentrated at the liver level, where it protects the liver cells from toxic molecules: in this case, Glutathione “binds” to the toxic metabolites, neutralizing them. Reduced Glutathione is in fact able to give up its hydrogen (H+), which acts as an acceptor of an electron (e-) coming from reactive oxygen molecules, that is, from free radicals. At this point, having eliminated the danger caused by free radicals, glutathione can regain its antioxidant activity and return to its reduced form. Glutathione’s ability to continuously regenerate itself is the reason why this molecule is considered the most powerful antioxidant in the human body. The biological functions of Glutathione support its clinical utility in various situations, first of all its ability to protect the liver from the action of toxic substances.

The oral intake of glutathione has always been the limiting factor** for its use in food supplements: the human intestine contains significant quantities of the enzyme gamma-glutamyltranspeptidase, responsible for the degradation of glutathione after oral ingestion. This molecule was therefore truly effective only if taken by injection. Thanks to the special absorption of GLR Setria® Sublingual, a new generation reduced glutathione supplement, it is possible to skip the enzymatic steps responsible for the loss of effectiveness of the molecule, guaranteeing the body optimal bioavailability of Glutathione.

Why is Glutathione so important? Twenty-four hours a day, seven days a week, free radicals are busy attacking our body at the cellular level. Scientists have discovered that this constant attack impacts our overall health and well-being, including the health of our tissues and their aging. It seems that fighting the damage caused by free radicals can allow us to age better and live a healthier life: for this reason, it is important to ensure our body has optimal levels of Glutathione, a molecule capable of effectively counteracting oxidative stress.

How ​​can GLR Setria® Sublingual help your body fight free radicals? Eating, exercising and even breathing are actions that can result in the creation of free radicals. These molecules, once formed, attack the body at the cellular level, stealing electrons from other molecules and setting off a chain reaction. SetriBol provides the body with reduced Glutathione, a molecule that binds to free radicals, neutralizing their action.

Why is Glutathione called the “Master Antioxidant” or “King of Antioxidants”? Glutathione does not only neutralize free radicals: it also has the ability to reactivate other antioxidant molecules, such as vitamins C and E. Normally, in fact, after antioxidants (such as vitamin C and vitamin E) have done their job by inactivating free radicals, they themselves become unstable radicals. Glutathione helps recycle these molecules, bringing them back into function and extending their ability to attack free radicals: for this reason Glutathione is considered the “master” or “King” molecule of all the antioxidants in the body.

How ​​does GLR Setria® Sublingual help eliminate toxins? Glutathione supports the function of the liver, kidneys, GI tract and gut, the body’s main detoxification pathways. It works on two different fronts:

1. It helps eliminate toxins, ingested chemicals and potential carcinogens that the body has already absorbed;
2. It intercepts and neutralizes toxins in the GI tract before they are absorbed.

Why can GLR Setria® Sublingual also be useful for athletes? Scientific research seems to suggest that Setria® Glutathione can support the production of Nitric Oxide (NO) when combined with L-Citrulline and when used in endurance performance. **Setria® also seems to help maintain elevated NO levels, which may reduce fatigue and speed of recovery. GLR Setria® Sublingual can therefore provide an aid for strength training, maintaining the increase in post-workout nitric oxide production.