Regexil®

Yamamoto® Nutrition Regexil® is a melatonin-based dietary supplement with valerian, passion flower and chamomile, with GABA, eschschscholzia and saffron, suitable for adults.

Diet and training are the pivotal factors of the successful athlete, but sleep is certainly another crucial element, which is often critical for the athlete, especially during intensified phases of high psychophysical stress in training. In these delicate moments, many athletes have difficulty both in getting to sleep and in getting adequate sleep or rest. This can have wide-ranging repercussions for an athlete from ineffective muscle recovery, increased inflammatory status, unfavourable insulin sensitivity, inefficient immune system, poor concentration and increased susceptibility to trauma. For every bodybuilder, therefore, sleep is almost fundamental, because it affects so many factors, from muscular to metabolic, endocrine as well as pain sensitivity. Hundreds of studies demonstrate the tangible relationship between sleep and athletic performance: metabolic, respiratory, cardiovascular and motor capacities are all negatively impacted when rest is insufficient.

What is Regexil®?

Yamamoto® Nutrition wanted to take into account all the essential aspects for the athlete, and the sleep factor could not be overlooked. Thus was born Regexil®, one of the best products on the market effective in promoting falling asleep and sleep quality, formulated with a highly synergistic blend of valerian extract, passion flower, chamomile, eschscholzia, Saff’Activ®, GABA and Melatonin.

The dry extract of Valerian contains numerous compounds (such as valepotriates, lignans, alkaloids and essential oil containing valerenic acids) with sedative, calming, spasmolytic and myorelaxant actions, which reduce anxiety and combat stress, and promote sleep induction. These compounds act on GABAaergic control mainly by inhibiting the degradation and presynaptic reuptake of the inhibitory neurotransmitter GABA and promoting its synthesis. Thus, precisely because GABA has an inhibitory action, these substances that increase the activity of GABAergic synapses depress the activity of the central nervous system, with the desired relaxing and anxiolytic effect.

The Passion flower is one of the most widely used herbal and phytotherapeutic remedies to combat anxiety and insomnia. Its calming and sedative effect is attributed to flavonoids and the many other components the extract contains (such as alkaloids, phytosterols, phenolic acids, coumarins, heterosides, cyanogenes). Passionflower is also used to induce muscular relaxation due to its spasmodic and relaxing action on the nervous system. In synergy with Chamomile, it has a beneficial effect not only on the nervous system, but also on the digestive and immune systems, having anti-inflammatory and carminative properties.

Saffron is a spice known for its use in cooking, but also used in traditional medicine since antiquity to improve mood. The patented Saffr’Activ®** provides bioactive compounds known for their mood-enhancing action. Saffron is in fact able to influence serotonin levels in the body. Serotonin is a hormone that influences mood, satiety, appetite, compulsivity and anxiety, and saffron has been shown in several studies to inhibit serotonin reuptake by blocking its SERT transporter, so that more serotonin is released in the brain, and this participates in the induction of a state of well-being and good mood.

The aqueous extract of Eschscholtzia, obtained from the Californian plant Eschscholtzia californica, contains several molecules with biological activity such as flavonoids, carotenoids and alkaloids. It is precisely the alkaloids, and in particular californidin and protropin, that act by exerting a sedative action on the central nervous system: they can induce sleep and have an anxiolytic effect. Several studies have confirmed the sedative properties of this plant, which has been used in folk medicine for centuries to treat insomnia and reduce agitation. Its action therefore allows better sleep and promotes relaxation not only of the body but also of the mind.

The main function of γ-aminobutyric acid or GABA as an inhibitory neurotransmitter is to slow down brain activity.

This neurotransmitter is involved in several aspects: vision, sleep, muscle tone and motor control. Its action is therefore not only targeted at the nervous system, but also extends to the intestines, stomach, bladder, lungs, liver, skin, spleen, muscles, kidneys, pancreas and reproductive organs. One of the most important functions of γ-aminobutyric acid is its ability to reduce stress and anxiety. When its levels are low, the likelihood of feeling anxious, tired and highly sensitive to stimuli increases. GABA therefore complements the Regexil® formula by increasing the brain waves associated with a relaxed state (called alpha waves) and decreasing those associated with stress and anxiety (beta waves).

In a powerful blend to combat sleep problems, the now well-known Melatonin, an indispensable element in rebalancing the body’s circadian rhythms, could not be missing.

Melatonin, also known as the ‘sleep hormone’, not only acts as a regulator but also directly induces sleep in those suffering from phase delay syndrome (DSP) or early insomnia.

These sufferers find it difficult to fall asleep: in these cases, melatonin helps shorten the time it takes to fall asleep, without, however, altering the sleep architecture, and consequently not altering the balance between the alternation of N-REM and REM phases.

The efficacy of REGEXIL® is further emphasised by the fact that the elements it contains are incorporated in a latest-generation triple-layer tablet, featuring differentiated-release technology, chosen to optimise the gradual and targeted release of each element over time.

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