Ashwagandha KSM-66®

Ashwagandha KSM-66® is the Yamamoto® Research dietary supplement that provides 600 mg of dry Ashwagandha root extract per dose, standardized to 5% withanolides and certified KSM-66®, ensuring potency, safety, and efficacy.

Ashwagandha (Withania somnifera), also known as Indian Ginseng, is one of the most renowned and powerful healing herbs in Ayurvedic medicine. It has been traditionally used for centuries for its tonic and adaptogenic properties—capable of supporting the body’s ability to manage physical and mental fatigue.

For thousands of years, the root of this plant has served as a phytotherapeutic remedy used to enhance the body’s non-specific resistance to stress, anxiety, and fatigue, while promoting a calmer, more relaxed state. Scientific research has also attributed to Ashwagandha anti-inflammatory, cardioprotective, neuroprotective, and immunomodulatoryproperties.

What does an “adaptogenic effect” mean?

Ashwagandha KSM-66® is distinguished by its ability to optimize the body’s stress response, helping regulate metabolic functions and enhance resilience to both emotional and physical stressors. This adaptogenic effect plays a key role in promoting mental wellness and emotional balance.

It appears to influence neuron receptor activity by facilitating the binding of GABA (Gamma-Aminobutyric Acid)—one of the most important inhibitory neurotransmitters in the central nervous system—to its receptors, thereby calming the nervous system and reducing the effects of stress.

What makes KSM-66® Ashwagandha unique?

The patented KSM-66® extraction process delivers the highest concentration of withanolides available in a root-only extract, standardized to 5%. Withanolides are steroidal lactones, and along with alkaloids and other phytochemicals, they represent the key active compounds responsible for the many benefits of Ashwagandha.

KSM-66® is backed by numerous scientific studies supporting its quality, safety, and clinical effectiveness.

The extraction method also follows a traditional Ayurvedic technique, involving pre-treatment of Ashwagandha roots with milk, which helps retain both hydrophilic (water-soluble) and lipophilic (fat-soluble) constituents. This process preserves the full spectrum of bioactive compounds, ensuring maximum efficacy.

Additional Features

• Suitable for vegetarian diets

• Every production batch is gluten-tested, making it safe for individuals with celiac disease

• Free from artificial additives and fillers

Scientific References

• Singh N, Bhalla M, de Jager P, Gilca M. An overview on Ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011.

• Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev. 2000.

• Bhattacharya SK, et al. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000.

• Sengupta P, et al. Role of Withania somnifera (Ashwagandha) in the management of male infertility. Reprod Biomed Online. 2018.

• Kuboyama T, et al. Effects of Ashwagandha on neurodegenerative diseases. Biol Pharm Bull. 2014.

• Choudhary MI, et al. Cholinesterase inhibiting withanolides from Withania somnifera. Chem Pharm Bull (Tokyo). 2004.